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Synbiotic preparation in men suffering from functional constipation: a randomised controlled trial.
R Fateh1, S Iravani, M Frootan
1School of Medicine, Tehran University of Medical Sciences, IR. rouzbehfateh@student.tums.ac.ir
Swiss Medical Weekly
|August 2, 2011
Summary
A synbiotic preparation significantly improved stool frequency and consistency in men with functional constipation over 4 weeks. No adverse effects were reported, suggesting potential benefits for this condition.
Area of Science:
- Gastroenterology
- Microbiome Research
- Clinical Nutrition
Background:
- Functional constipation affects a significant portion of the male population.
- Synbiotics, combining prebiotics and probiotics, offer a potential therapeutic avenue.
- Evaluating commercial synbiotic efficacy in male functional constipation is crucial.
Purpose of the Study:
- To assess the impact of a commercial synbiotic preparation on functional constipation in adult males.
- To determine changes in stool frequency and consistency.
Main Methods:
- A randomized controlled trial involving 66 adult men with functional constipation.
- Participants received either a synbiotic mixture or a placebo twice daily for 4 weeks.
- Stool frequency and Bristol stool form score were primary outcome measures.
Main Results:
- The synbiotic group showed a significant increase in stool frequency at weeks 2 and 4 compared to placebo (p=0.02).
- Significant improvements in Bristol stool form score were observed in the synbiotic group at weeks 2 and 4 (p=0.006).
- No adverse effects were reported in the synbiotic group.
Conclusions:
- The studied synbiotic preparation demonstrated efficacy in improving stool frequency and consistency in males with functional constipation.
- Further research with longer follow-up periods and diverse populations (females, elderly) is warranted.
- This synbiotic may be a beneficial option for managing functional constipation in men.
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