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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

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Intravitreal gentamicin-induced macular infarction: SD-OCT features.

Anita R Shirodkar¹, Avinash Pathengay, Harry W Flynn

¹Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA.

Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye

|August 3, 2011

Summary

This case report details vision loss after endophthalmitis treatment. Spectral-domain optical coherence tomography (SD-OCT) revealed inner retinal damage from intravitreal gentamicin, with the outer retina remaining intact.

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Area of Science:

Ophthalmology
Medical Imaging

Background:

Endophthalmitis is a serious intraocular infection often requiring prompt treatment.
Phacoemulsification is a common cataract surgery technique.
Intravitreal antibiotics are a standard treatment for endophthalmitis.

Observation:

A 75-year-old woman developed acute endophthalmitis post-phacoemulsification.
Treatment with vancomycin, ceftazidime, and gentamicin resulted in persistent visual loss.
Ocular examination showed a pale disc, retinal hemorrhages, and nerve fiber layer infarcts.

Findings:

Fluorescein angiography indicated macular vascular non-perfusion.
Spectral-domain optical coherence tomography (SD-OCT) demonstrated diffuse retinal thinning and absence of foveal depression.
SD-OCT revealed increased reflectivity in the nerve fiber and ganglion cell layers, with an intact inner segment/outer segment junction.

Implications:

This case highlights potential macular infarction following intravitreal gentamicin use.
SD-OCT imaging is crucial for characterizing inner retinal changes in such cases.
Understanding these specific SD-OCT findings aids in diagnosing and managing post-infectious or treatment-related retinal damage.