Development of a cholesterol-conjugated fluorescent sensor for site-specific detection of zinc ion at the plasma membrane
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Characterizing Mammalian Zinc Transporters Using an In Vitro Zinc Transport Assay
Published on: June 2, 2023
Shohei Iyoshi1, Masayasu Taki, Yukio Yamamoto
1Graduate School of Human and Environmental Studies, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Organic Letters
|August 3, 2011
Abstract:
A cholesterol-conjugated fluorescence Zn(2+) sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn(2+) sensor to the cell membrane, allowing the sensor to probe changes in the Zn(2+) concentration in a localized area of the cell.
