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Digital optical tomography system for dynamic breast imaging.

Molly L Flexman¹, Michael A Khalil, Rabah Al Abdi

¹Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, New York 10027, USA. mlf2129@columbia.edu

Journal of Biomedical Optics

|August 3, 2011

Summary

This study introduces a novel digital continuous-wave optical tomography system for enhanced breast cancer detection. The system can identify invasive carcinoma by analyzing hemodynamic responses during breath holds, improving screening capabilities.

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Area of Science:

Medical Imaging
Biophysics
Oncology

Background:

Diffuse optical tomography (DOT) shows potential for breast cancer screening and chemotherapy monitoring.
Dynamic imaging during external stimuli (pressure, respiration) can reveal additional tumor-specific information.
Current DOT systems require optimization for speed and simultaneous bilateral imaging.

Observation:

A new digital continuous-wave optical tomography system was developed for simultaneous bilateral breast imaging.
The system employs a master-slave digital signal processor architecture for high dynamic range (160 dB) and fast frame rates (1.7 Hz).
It utilizes 32 sources, 64 detectors, and 4 wavelengths per breast for detailed data acquisition.

Findings:

The system successfully identified an invasive carcinoma in a preliminary patient study.
Detection was based on the hemodynamic response observed during a breath-hold maneuver.
This demonstrates the system's capability to detect tumors through dynamic physiological changes.

Implications:

This advanced DOT system offers a promising non-invasive tool for early breast cancer detection.
Fast, simultaneous bilateral imaging could significantly improve screening efficiency and diagnostic accuracy.
Monitoring hemodynamic responses provides a novel approach for tumor characterization and treatment assessment.