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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Related Experiment Video

Updated: May 30, 2026

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay
08:34

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay

Published on: July 15, 2025

Reduced brain insulin-like growth factor I function during aging.

Alexandre Pastoris Muller1, Ana M Fernandez2, Clarissa Haas1

  • 1Departamento de Bioquímica, ICBS, UFRGS. Programa de Pós Graduação em Ciências Biológicas-Bioquímica. Porto Alegre, RS, Brazil.

Molecular and Cellular Neurosciences
|August 3, 2011
PubMed
Summary
This summary is machine-generated.

Aging impairs brain insulin-like growth factor I (IGF-I) function despite increased uptake capacity. Reduced IGF-I signaling in aged mice contributes to cognitive decline, highlighting the importance of IGF-I brain entry.

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Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
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Related Experiment Videos

Last Updated: May 30, 2026

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay
08:34

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Published on: July 15, 2025

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

Area of Science:

  • Neuroscience
  • Aging Research
  • Endocrinology

Background:

  • Peripheral insulin-like growth factor I (IGF-I) function declines with age.
  • The impact of aging on IGF-I function within the brain remains largely uncharacterized.
  • Serum IGF-I can potentially access the brain via the cerebrospinal fluid (CSF).

Purpose of the Study:

  • To investigate the route of serum IGF-I entry into the aged brain.
  • To assess the functional status of IGF-I signaling in the aging brain.
  • To correlate brain IGF-I function with cognitive performance in aged mice.

Main Methods:

  • Administration of human IGF-I via intraperitoneal injection in young and aged mice.
  • Measurement of human IGF-I levels in cerebrospinal fluid (CSF) and plasma.
  • Analysis of brain IGF-I receptor levels and downstream signaling pathway activation (Akt/GSK3).

Main Results:

  • Aged mice exhibited higher CSF levels of human IGF-I post-injection, indicating increased uptake capacity.
  • Despite enhanced uptake, naive aged mice showed reduced brain and plasma IGF-I levels.
  • IGF-I signaling, including receptor activation, was significantly impaired in the aged brain.

Conclusions:

  • Increased brain IGF-I receptor levels and enhanced serum uptake capacity are insufficient to counteract age-related functional decline.
  • Deteriorated IGF-I signaling in the aged brain contributes to cognitive impairment.
  • Preserved serum IGF-I input to the brain is crucial for maintaining cognitive function during aging.