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Fasting might not be necessary before lipid screening: a nationally representative cross-sectional study
Michael J Steiner1, Asheley Cockrell Skinner, Eliana M Perrin
1Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA. msteiner@med.unc.edu
Pediatrics
|August 3, 2011
Summary
Fasting before pediatric lipid screening shows minimal impact on cholesterol levels. Non-fasting tests for total cholesterol, HDL, and LDL are reliable, simplifying childhood screening.
Area of Science:
- Pediatric lipidology
- Clinical chemistry
- Public health
Background:
- Fasting lipid screening in children faces practical barriers.
- Adult studies suggest non-fasting lipid tests are reliable.
- Investigating non-fasting protocols for pediatric lipid screening is warranted.
Purpose of the Study:
- To evaluate population-level differences in pediatric lipid values based on fasting duration.
- To determine if fasting is necessary for accurate pediatric lipid screening.
Main Methods:
- Utilized National Health and Nutrition Examination Survey (1999-2008) data.
- Analyzed total cholesterol (TC), HDL, LDL, and triglycerides based on fasting times.
- Employed ordinary least-squares regression, controlling for covariates.
Main Results:
- Fasting showed a small positive effect on TC, HDL, and LDL (2-5 mg/dL higher with 12-hour fast).
- Triglyceride levels were negatively affected by fasting (7 mg/dL lower).
- Differences observed were generally not clinically significant.
Conclusions:
- Non-fasting pediatric lipid screening yields comparable results to fasting.
- Small differences in lipid values are unlikely to be clinically important.
- Eliminating fasting requirements could reduce the burden of childhood cholesterol screening.
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