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Updated: May 30, 2026

10:38
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
Published on: January 15, 2018
Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting
Francesca Mastrotto1, Paolo Caliceti, Vincenzo Amendola
1Department of Pharmaceutical Sciences, University of Padua, Padova, Italy.
Abstract:
The function of cell-specific ligands on gold nanoparticles can be selectively gated by the action of co-grafted thermosensitive polymers. Below the LCST the responsive chain-extended polymers prevent cell-surface receptors from accessing the affinity ligands while above the LCST, the polymers collapse exposing the ligands and allowing binding to receptors, which in turn promotes cell internalisation.

