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Related Concept Videos

Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in the...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...

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Related Experiment Video

Updated: May 30, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Does sustained weight loss reverse the metabolic syndrome?

Annie Ferland1, Robert H Eckel

  • 1Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Anschutz Medical Center, 12801 E. 17th Avenue, Aurora, CO 80045, USA.

Current Hypertension Reports
|August 3, 2011
PubMed
Summary

Metabolic syndrome (MetS) is increasingly prevalent, driven by obesity. Sustained weight loss offers a key strategy to reverse its metabolic complications, improving overall health outcomes.

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Area of Science:

  • Metabolic Medicine
  • Obesity Research
  • Cardiovascular Health

Background:

  • The metabolic syndrome (MetS) prevalence is rapidly increasing in North America.
  • Currently, MetS affects 34.3% of the population, with projections indicating continued rise.
  • The obesity epidemic is a significant driver of increasing MetS rates.

Purpose of the Study:

  • To review clinical and experimental evidence on reversing metabolic complications associated with MetS.
  • To highlight the role of sustained weight loss in mitigating MetS components.

Main Methods:

  • Literature review of clinical studies.
  • Analysis of experimental evidence.
  • Synthesis of data on weight loss interventions and MetS reversal.

Main Results:

  • Sustained weight loss is a primary target for reversing MetS.
  • Evidence supports the beneficial reversal of metabolic complications following weight loss.
  • Weight maintenance is crucial for long-term benefits.

Conclusions:

  • Sustained weight loss is effective in reversing metabolic syndrome components.
  • Interventions promoting weight loss and maintenance are vital for public health.
  • Further research should focus on long-term strategies for MetS management.