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[Effects of ferulic acid on bFGF-treated PC12 cells]
Lian-feng Lin1, Fei Xiao, Yong-chang Lai
1Department of Pharmacology, Medical College, Jinan University, China. tlinlf@hotmail.com
Objective:
To explore the effect and mechanism of ferulic acid on differentiation in bFGF-treated PC12 cells.
Methods:
The length of neurite outgrowth and the percentage of PC12 cells induced in the presence of 0 ng/mL or 1 ng/mL bFGF were assayed.
Results:
Compared with that of control group,ferulic acid could enhance the differentiation effect of bFGF (1 ng/mL) in PC12 cells (P < 0.01) and the enhancing effect could be blocked by the specific MAPK kinase inhibitor, PD98059.
Conclusion:
Ferulic acid potentiates neurite outgrowth in bFGF-treated PC12 cells by MAPK-dependent signaling pathway.