Related Experiment Video

Updated: May 30, 2026

Multimodality Diagnosis of Mesenteric Ischemia
05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

NSAID-Associated Perforation of a Meckels Diverticulum: A Case Report

Avneet S Brar1, Richdeep S Gill, Sumeet S Gill

  • 1Department of Family Medicine, University of Calgary, Calgary, Alberta, Canada.

Journal of Clinical Medicine Research
|August 4, 2011
PubMed
Abstract

Insights

This case report documents a rare instance of Meckel's diverticulum perforation linked to excessive Nonsteroidal Anti-Inflammatory Drug (NSAID) use. The findings suggest a potential mechanism similar to NSAID-induced gastric ulcer perforation.

Area of Science:

  • Gastroenterology
  • Surgical Case Reports

Background:

  • Meckel's diverticulum is the most common congenital gastrointestinal malformation.
  • Heterotopic gastric mucosa is the most frequent ectopic tissue found in Meckel's diverticula, often presenting with bleeding.
  • Perforation of Meckel's diverticulum is a rare but serious complication.

Observation:

  • A 17-year-old female presented with acute abdominal pain after excessive Nonsteroidal Anti-Inflammatory Drug (NSAID) ingestion.
  • Radiographic evidence of free intra-abdominal air indicated a perforated viscus.
  • Exploratory laparotomy revealed and necessitated the resection of a perforated Meckel's diverticulum.

Findings:

  • This case presents the first documented instance of NSAID-associated Meckel's diverticulum perforation.
  • While NSAID-induced bleeding from heterotopic gastric mucosa is known, a direct link to perforation was previously undocumented.
  • The mechanism may mirror that of NSAID-induced gastric ulcer perforation.

Implications:

  • The widespread use of NSAIDs warrants increased awareness of their potential to cause Meckel's diverticulum perforation.
  • This documentation suggests a potential causal relationship between NSAID use and Meckel's diverticulum perforation.
  • Further investigation into this association is crucial for patient safety and clinical management.

More Related Videos

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy04:05

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Published on: August 22, 2025

Related Concept Videos

Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus.
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...