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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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The evidence base to select a method for assessing glaucomatous visual field progression.

Paul J G Ernest1, Jan S A G Schouten, Henny J M Beckers

  • 1Department of Epidemiology, Maastricht University, Maastricht, the Netherlands. p.j.g.ernest@gmail.com

Acta Ophthalmologica
|August 5, 2011
PubMed
Summary

Evaluating glaucomatous visual field progression requires careful method selection. This review found 48 valid methods, but quantifiably assessing progression is key for guiding patient treatment and future research.

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Area of Science:

  • Ophthalmology
  • Clinical Research
  • Medical Technology Assessment

Background:

  • Numerous methods exist for assessing glaucomatous visual field progression.
  • Systematic evaluation of these methods' properties is lacking.
  • Glaucoma diagnosis and management rely on accurate visual field assessment.

Purpose of the Study:

  • To systematically review and summarize the evidence for selecting a method to assess glaucomatous visual field progression.
  • To answer key questions regarding the variety, validity, and reproducibility of existing methods.
  • To guide clinicians in choosing appropriate methods for monitoring glaucoma progression.

Main Methods:

  • Systematic literature review of 412 articles.
  • Identification and categorization of 301 different visual field progression assessment methods.
  • Analysis of evidence for method validity and reproducibility.

Main Results:

  • The Humphrey Field Analyzer was the most commonly used device (54%).
  • No data on method reproducibility were found.
  • Evidence for validity exists for 48 methods, with 12 recommended for consideration.
  • Methods vary in sensitivity, specificity, and predictive values.

Conclusions:

  • The current evidence base for selecting progression assessment methods is imperfect.
  • Method selection should align with the clinical purpose of progression assessment.
  • Methods quantifying visual field progression rate are most suitable for guiding clinical decisions.
  • Further research is needed to compare methods' impact on patient quality of life.