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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

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Related Experiment Video

Updated: May 30, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Cyclodextrins in delivery systems: Applications.

Gaurav Tiwari1, Ruchi Tiwari, Awani K Rai

  • 1Jaipur National University, Jagatpura, Jaipur, Rajasthan, India.

Journal of Pharmacy & Bioallied Sciences
|August 5, 2011
PubMed
Summary
This summary is machine-generated.

Cyclodextrins (CDs) enhance drug solubility, bioavailability, and stability. These cyclic oligosaccharides are key in pharmaceutical formulations, with CD-containing polymers showing promise for nucleic acid delivery.

Keywords:
Complexationcolonrectaltargeted drug deliverytransdermal

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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Area of Science:

  • Pharmaceutical Science
  • Polymer Chemistry

Background:

  • Cyclodextrins (CDs) are cyclic oligosaccharides with distinct hydrophilic and lipophilic properties.
  • Their large size and hydrogen bonding capabilities limit lipophilic membrane permeation.
  • CDs are widely utilized in the pharmaceutical industry as complexing agents.

Purpose of the Study:

  • To review current cyclodextrin-based therapeutics.
  • To discuss potential future applications of CDs in drug delivery.
  • To present the use of CD-containing polymers, particularly for nucleic acid delivery.

Main Methods:

  • Literature review of CD applications in pharmaceuticals.
  • Analysis of CD-containing polymers for drug delivery systems.
  • Examination of studies on CD efficacy in various drug formulations.

Main Results:

  • CDs effectively increase the aqueous solubility, bioavailability, and stability of poorly soluble drugs.
  • Approximately 30 pharmaceutical products globally utilize drug/CD complexes.
  • CD-containing polymers offer unique capabilities for drug and nucleic acid delivery.

Conclusions:

  • Cyclodextrins are versatile pharmaceutical excipients with established and emerging applications.
  • CD-based drug delivery systems demonstrate broad applicability across various formulations.
  • CD-containing polymers represent a significant advancement in targeted drug and nucleic acid delivery.