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Drug glucosidation.

B K Tang1

  • 1Department of Pharmacology, University of Toronto, Ontario, Canada.

Pharmacology & Therapeutics
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Drug glucosidation, a process in vertebrates, was reviewed. Genetic factors and interethnic variations influence amobarbital-N-glucoside formation, with some individuals lacking this metabolic pathway.

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Area of Science:

  • Pharmacology
  • Genetics
  • Biochemistry

Background:

  • Drug glucosidation is a known metabolic process in vertebrates.
  • Eleven drug glucosides' properties are reviewed.
  • Variations in drug metabolism exist among individuals.

Purpose of the Study:

  • To review the properties of eleven drug glucosides.
  • To investigate the genetic basis of amobarbital-N-glucoside formation.
  • To explore interethnic variations in drug metabolism.

Main Methods:

  • Literature review of drug glucosidation.
  • Analysis of amobarbital-N-glucoside formation in individuals.
  • Genetic analysis using twin studies.

Main Results:

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  • Three out of 200 individuals showed a complete lack of amobarbital-N-glucoside formation.
  • A deficiency in this pathway appears to be a recessive trait.
  • Autosomal genes likely regulate N-glucoside formation.
  • Interethnic variations in average drug metabolism values were observed.

Conclusions:

  • Amobarbital-N-glucoside formation is influenced by genetic factors.
  • A single pair of autosomal genes may control N-glucoside formation.
  • Interethnic differences in drug metabolism warrant further investigation.