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The stillbirth collaborative research network postmortem examination protocol.

Halit Pinar1, Matthew A Koch, Hal Hawkins

  • 1Division of Perinatal Pathology, Women and Infants Hospital, Brown University, Alpert School of Medicine, Providence, Rhode Island, USA. halit.pinar@gmail.com

American Journal of Perinatology
|August 5, 2011
PubMed
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A standardized postmortem examination (PM) protocol was developed to investigate stillbirth (SB) causes. This Stillbirth Cooperative Research Network (SCRN) protocol enhances stillbirth evaluation consistency across the United States.

Area of Science:

  • Perinatal pathology
  • Epidemiology
  • Biostatistics

Background:

  • Limited guidance exists on optimal postmortem examination (PM) for determining stillbirth (SB) pathogenesis.
  • A workshop sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) highlighted this knowledge gap.

Framework:

  • A standardized perinatal PM protocol was developed by perinatal pathologists, clinicians, epidemiologists, and biostatisticians.
  • This framework was designed for the NICHD-supported Stillbirth Cooperative Research Network (SCRN).

Implementation:

  • The SCRN PM protocol was successfully implemented across four tertiary care centers.
  • The protocol was applied to a population-based study involving 663 women experiencing stillbirth.
  • 84.5% of women consented to PM for 572 stillborn infants.

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Implications:

  • The standardized protocol ensures consistent stillbirth evaluation across US centers.
  • This model facilitates the development of novel testing and approaches to improve PM yield.
  • Enhanced understanding of stillbirth causes can be achieved through consistent data collection.