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Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Limonoids from Meliaceae with lipid peroxidation inhibitory activity
Robert G Fowles1, Baldwin S Mootoo, Russel S Ramsewak
1Department of Agricultural, Food and Nutritional Science, T6G 2P5, University of Alberta, Edmonton, Alberta, Canada.
Natural Product Communications
|August 6, 2011
Summary
Natural limonoids from Meliaceae and their semi-synthetic derivatives were evaluated for antioxidant activity. Several analogues demonstrated superior lipid peroxidation inhibition compared to synthetic antioxidants like BHA and TBHQ.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Pharmacology
Background:
- The Meliaceae family is a rich source of bioactive limonoids.
- Investigating the antioxidant properties of these natural compounds and their derivatives is crucial for potential therapeutic applications.
Purpose of the Study:
- To evaluate the antioxidant activity of five natural limonoids from Meliaceae and their semi-synthetic analogues.
- To compare the efficacy of these compounds against lipid peroxidation with established synthetic antioxidants.
Main Methods:
- Lipid peroxidation (LPO) inhibitory assays were performed on natural limonoids (compounds 1-5) and their semi-synthetic analogues (compounds 6-25).
- The antioxidant capacity was assessed by measuring the percentage of inhibition against LPO.
- Activity was benchmarked against positive controls Butylated hydroxyanisole (BHA) and tert-Butylhydroquinone (TBHQ).
Main Results:
- Natural limonoids 1, 3, and 4 exhibited significant LPO inhibition (85.6%, 77.3%, and 61.2%, respectively).
- Semi-synthetic analogues, particularly compounds 10, 16-17, 21-22, and 25, demonstrated excellent antioxidant activity, with inhibition rates up to 100%.
- Several analogues surpassed the inhibitory activity of BHA (91.3%) and TBHQ (95.7%).
Conclusions:
- Semi-synthetic modification of Meliaceae limonoids can significantly enhance antioxidant properties.
- These novel limonoid derivatives represent promising candidates for development as potent antioxidants.
- Further research into the mechanism of action and safety profiles is warranted.
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