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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
The Proteasome Structure01:17

The Proteasome Structure

The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

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Related Experiment Video

Updated: May 30, 2026

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

The International Proteomics Tutorial Programme--reaching out to the next generation proteome scientists.

Peter James, György A Marko-Varga

    Journal of Proteome Research
    |August 6, 2011
    PubMed
    Summary

    Proteomics organizations launch a joint Tutorial Program for young scientists. This initiative offers freely available teaching resources on core proteomics techniques for Masters/PhD students.

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    Area of Science:

    • Proteomics
    • Scientific Education
    • Biochemistry

    Background:

    • Proteomics organizations play a crucial role in training scientists and disseminating knowledge.
    • Existing educational gaps for early-career researchers in proteomics necessitate structured learning programs.

    Discussion:

    • The Human Proteome Organisation (HUPO) and European Proteomics Association (EuPA) are collaborating on a joint Tutorial Program.
    • This program targets Masters/PhD students with foundational knowledge in biology, biochemistry, and statistics.
    • The curriculum focuses on core proteomics techniques and fundamental concepts for newcomers to the field.

    Key Insights:

    • The Tutorial Program provides a comprehensive introduction to proteomics for early-career scientists.
    • Educational materials include review/teaching articles and slide presentations for classroom use.
    • All resources will be accessible online for free educational purposes.

    Outlook:

    • This initiative aims to enhance proteomics education globally.
    • The program's open-access nature promotes widespread adoption and knowledge sharing.
    • Future iterations may expand content to advanced proteomics topics and methodologies.