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Evolving surgical techniques of and indications for corneal transplantation in Ontario from 2000 to 2009
Corey Boimer1, Kenneth Lee, Linda Sharpen
1University of Toronto Faculty of Medicine, ON, Canada.
Objective:
To determine the changes in the leading indications for and the preferred surgical techniques of corneal transplantation in Ontario over a 9-year period.
Design:
Retrospective review of Eye Bank of Canada (Ontario Division) records.
Participants:
Recipients of corneal transplants performed in Ontario between 2000 and 2009, totaling 6240 patients.
Methods:
Records of all corneal tissues sent for transplantation in Ontario by the Eye Bank of Canada (Ontario Division) from July 1 2000 to June 30 2009 were reviewed. The records consist of recipient information forms completed by surgeons at the time of corneal transplant surgery. Of the 8186 available recipient information forms, 7755 (94.7%) were sufficiently complete to meet the inclusion criteria.
Results:
The leading indications for corneal transplantation were pseudophakic corneal edema (28.3%), regraft (21.5%), Fuchs dystrophy (16.6%), and anterior keratoconus (13.8%). Beginning in 2006, there has been a shift in the proportion of corneal transplants performed using Descemet's stripping automated endothelial keratoplasty (DSAEK) and deep anterior lamellar keratoplasty, from 2.4% to 36.1% of all corneal transplants. Concomitantly, DSAEK has replaced penetrating keratoplasty (PKP) as the technique of choice when corneal transplantation is indicated for Fuchs' dystrophy (139 DSAEKs vs. 68 PKPs in 2009) and for pseudophakic corneal edema (118 DSAEKs vs. 115 PKPs in 2009).
Conclusion:
The indications for PKP in this study agree with the North American literature. In recent years, partial-thickness transplants have gained favor over PKP for select indications in Ontario. These changes reflect the future direction of corneal transplantation and will have implications on the supply of and demand for tissues.
Insights
Corneal transplantation in Ontario shows a shift towards partial-thickness procedures like DSAEK, replacing penetrating keratoplasty for conditions such as Fuchs dystrophy. This trend impacts tissue demand and supply for corneal transplants.
Area of Science:
- Ophthalmology
- Transplantation Surgery
Background:
- Corneal transplantation is a common procedure to restore vision.
- Indications and surgical techniques evolve with medical advancements.
Purpose of the Study:
- To analyze trends in corneal transplantation indications and surgical techniques in Ontario from 2000 to 2009.
- To identify shifts in the preference for specific keratoplasty procedures.
Main Methods:
- Retrospective review of 7755 corneal transplant recipient records from the Eye Bank of Canada (Ontario Division).
- Data analysis covered the period from July 1, 2000, to June 30, 2009.
Main Results:
- Leading indications included pseudophakic corneal edema (28.3%), regraft (21.5%), Fuchs dystrophy (16.6%), and keratoconus (13.8%).
- A significant increase in partial-thickness transplants (DSAEK/DALK) was observed from 2.4% to 36.1% after 2006.
- DSAEK increasingly replaced PKP for Fuchs dystrophy and pseudophakic corneal edema.
Conclusions:
- The study confirms established indications for penetrating keratoplasty (PKP).
- Partial-thickness corneal transplants are gaining preference over PKP for specific indications in Ontario.
- These evolving trends in corneal transplantation will influence tissue utilization and availability.
