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Published on: January 26, 2019
Changes in sleep apnea after supraglottoplasty in infants with laryngomalacia
Rosser Powitzky1, Julie Stoner, Tyson Fisher
1Oklahoma University Health Science Center, Oklahoma City, OK, USA. rosser-powitzky@ouhsc.edu
Insights
Supraglottoplasty significantly improved moderate to severe obstructive sleep apnea in infants with laryngomalacia. Polysomnography can identify sleep apnea and measure outcomes after this surgery.
Area of Science:
- Pediatric Otolaryngology
- Sleep Medicine
- Respiratory Physiology
Background:
- Laryngomalacia is a common cause of stridor in infants.
- Obstructive sleep apnea (OSA) can be associated with laryngomalacia, impacting infant health.
- Surgical intervention like supraglottoplasty is considered for severe cases.
Purpose of the Study:
- To evaluate clinical and polysomnography outcomes in infants with laryngomalacia after supraglottoplasty.
- To assess the effectiveness of supraglottoplasty in improving sleep-disordered breathing.
- To determine the utility of polysomnography in managing these patients.
Main Methods:
- Retrospective review of infants (<1 year) undergoing polysomnography before and after supraglottoplasty.
- Analysis of changes in stridor, sleep-disordered breathing, swallowing, and polysomnography parameters.
- Statistical comparison using Wilcoxon signed-rank test.
Main Results:
- Significant improvements in apnea-hypopnea index (AHI) and obstructive apnea index (OAI) post-surgery.
- Improvements noted in O2 saturation and reduction in time spent with low saturation, though not always statistically significant.
- Postoperative AHI correlated with stridor improvement; dysphagia resolved in affected patients without complications.
Conclusions:
- Supraglottoplasty appears effective and safe for moderate to severe OSA in infants with laryngomalacia.
- Polysomnography is valuable for identifying OSA and objectively measuring outcomes post-supraglottoplasty.
- Further large-scale prospective studies are warranted to confirm these findings.
Objective:
To determine the clinical and polysomnography outcomes in infants with laryngomalacia undergoing supraglottoplasty.
Methods:
Infants (<1 year old) who underwent polysomnography pre- and post-supraglottoplasty at our tertiary referral center between 2003 and 2009 were reviewed retrospectively. Outcome measures included changes in stridor, sleep disordered breathing, swallowing, and polysomnography parameters before and after surgery. Pre- and postoperative distributions were compared using a Wilcoxon signed-rank test.
Results:
20 children met inclusion criteria. Statistically significant improvements were found in pre- to postoperative median values for apnea-hypopnea index (AHI) (median change: -6.4 points, p=0.02) and obstructive apnea index (median change: -2.9 points, p=0.01) values. Obstructive AHI, O₂ saturation nadir, and percentage of sleep spent with <90% O₂ saturation improved, although not significantly. Postoperative AHI scores correlated with improvements in stridor in 80% of patients. Stratification showed similar improvements in AHI after supraglottoplasty regardless of reflux treatment, secondary airway lesions, age at supraglottoplasty, or time lag between supraglottoplasty and postoperative polysomnography. Secondary airway lesions are the only potential confounders shown to have significantly better improvements in O₂ nadir. While the sleep study improved in patients with AHI >5, infants with AHI <5 had worse polysomnography parameter values postoperatively. Five patients had dysphagia that resolved within one month postoperatively; otherwise, supraglottoplasty resulted in no complications.
Conclusion:
Supraglottoplasty may be an effective and safe option to improve moderate to severe obstructive sleep apnea in infants with laryngomalacia. In addition, polysomnography may be useful in infants with laryngomalacia to identify obstructive sleep apnea and/or to objectively measure outcomes after supraglottoplasty. This pilot study warrants a larger, prospective, and controlled study to validate these findings.
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