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Toxoplasmosis

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...

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MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...

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Related Experiment Video

Updated: May 30, 2026

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

Published on: December 9, 2014

Changes in Toxoplasma diagnosis.

Jean M W Chatterton¹, Susan McDonagh¹, Neil Spence¹

¹Scottish Toxoplasma Reference Laboratory, Microbiology Department, Raigmore Hospital, Inverness IV2 3UJ, UK.

Journal of Medical Microbiology

|August 6, 2011

Summary

This summary is machine-generated.

Toxoplasma infection diagnosis shows shifts, with fewer symptomatic cases but more in immunocompromised patients. Despite a lower positive rate, current infections increased, especially in women of childbearing age, highlighting ongoing diagnostic importance.

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Last Updated: May 30, 2026

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

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Determination of Chemical Inhibitor Efficiency against Intracellular Toxoplasma Gondii Growth Using a Luciferase-Based Growth Assay

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Published on: April 29, 2020

Area of Science:

Medical Microbiology
Clinical Diagnostics
Parasitology

Background:

Serological laboratory workloads for toxoplasma infection detection are influenced by patient population clinical profiles.
Changes in clinical presentation necessitate re-evaluation of diagnostic strategies for toxoplasmosis.

Purpose of the Study:

To analyze changes in the clinical profile and serological results of patients tested for toxoplasma infection.
To assess the impact of evolving patient demographics on toxoplasmosis diagnostics over a decade.

Main Methods:

Comparative analysis of clinical data and laboratory results from two distinct periods (1999-2000 and 2009-2010).
Statistical evaluation of patient demographics, symptoms, immunocompromised status, and toxoplasma antibody prevalence.

Main Results:

A decrease in patients with current toxoplasma infection symptoms (612 vs. 335) and an increase in immunocompromised patients (275 vs. 531).
A decline in the overall percentage of positive toxoplasma antibody tests (53.9% vs. 37.5%), but an increase in identified current infections (48 vs. 35), particularly in females aged 20-39.
Positive results increased with age, indicating persistent toxoplasma infection risk.

Conclusions:

Significant shifts in the clinical profile of patients undergoing toxoplasma testing have occurred.
Despite changes, effective diagnostic strategies for toxoplasma infection remain crucial, with a notable rise in identified infections among women of childbearing age.