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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

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Apical hypertrophic cardiomyopathy presenting as recurrent unexplained syncope.

Yusuf Kasirye1, Janaki Ram Manne, Narendranath Epperla

  • 1Department of Internal Medicine, Marshfield Clinic, 50 Sherry Avenue, Park Falls, WI 54552, USA. kasirye.yusuf@marshfieldclinic.org

Clinical Medicine & Research
|August 6, 2011
PubMed
Summary

Apical hypertrophic cardiomyopathy (AHC) is a rare heart condition. Early diagnosis is crucial, and unique electrocardiogram (ECG) findings can provide vital clues, even when cardiac MRI is the gold standard.

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Area of Science:

  • Cardiology
  • Medical Diagnostics

Background:

  • Apical hypertrophic cardiomyopathy (AHC) is a rare variant of hypertrophic cardiomyopathy.
  • First described in 1976, understanding of AHC has evolved significantly.
  • Cardiac magnetic resonance imaging (CMR) is the gold standard for diagnosing AHC.

Observation:

  • This case highlights a 47-year-old male patient presenting with recurrent syncope.
  • Electrocardiogram (ECG) anomalies suggestive of AHC were initially overlooked.
  • Classical ECG findings were evident upon admission, leading to rapid diagnosis.

Findings:

  • Unique electrocardiographic features are critical for the initial diagnosis of AHC.
  • ECG analysis can provide early diagnostic clues for AHC.
  • The case underscores the importance of recognizing subtle ECG patterns in AHC.

Implications:

  • Increased clinical awareness of ECG findings in AHC is essential.
  • Prompt ECG interpretation can expedite AHC diagnosis.
  • This emphasizes the complementary role of ECG alongside advanced imaging like CMR.