Related Experiment Video
Updated: May 30, 2026

Studying DNA Looping by Single-Molecule FRET
Published on: June 28, 2014
Pre-melting dynamics of DNA and its relation to specific functions
Boian Alexandrov1, Nikolaos K Voulgarakis, Kim O Rasmussen
1Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Abstract:
We discuss connections between the nonlinear dynamics of double-stranded DNA, experimental findings, and specific DNA functions. We begin by discussing how thermally induced localized openings (bubbles) of the DNA double strand are important for interpreting dynamic force spectroscopy data. Then we demonstrate a correlation between a sequence-dependent propensity for pre-melting bubble formation and transcription initiation and other regulatory effects in viral DNA. Finally, we discuss the possibility of a connection between DNA dynamics and the ability of repair proteins to recognize ultraviolet (UV) radiation damage sites.
Related Concept Videos
Nucleosome Remodeling
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
The DNA Helix
The DNA Helix
DNA Helicases
DNA as a Genetic Template
DNA Topoisomerases
Types and Mechanism of action
Topoisomerases are divided into two main types. Type I...

