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Updated: May 30, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

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Published on: June 13, 2021

Acromegaly and pregnancy.

P Caron1

  • 1Pôle cardiovasculaire et métabolique, service d'endocrinologie, maladies métaboliques et nutrition, CHU Rangueil-Larrey, 24, chemin de Pouvourville, TSA 30030, 31059 Toulouse cedex 9, France.

Annales D'Endocrinologie
|August 9, 2011
PubMed
Summary
This summary is machine-generated.

Pregnancy in women with growth hormone (GH)-secreting pituitary adenomas requires careful management. Considerations include effects on the tumor, maternal-fetal health, and treatment safety during gestation.

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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Published on: January 17, 2018

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Last Updated: May 30, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

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Published on: June 13, 2021

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Oncology

Background:

  • Acromegaly, caused by excess growth hormone (GH), presents unique challenges during pregnancy.
  • GH-secreting pituitary adenomas require careful monitoring throughout gestation.

Purpose of the Study:

  • To outline the key considerations for managing pregnant women with acromegaly.
  • To review the impact of pregnancy on pituitary adenomas and vice versa.
  • To assess the safety of various treatments for acromegaly during pregnancy.

Main Methods:

  • Literature review of studies on acromegaly, pregnancy, and pituitary adenoma management.
  • Analysis of hormonal changes (GH/IGF-1) during pregnancy in acromegaly patients.
  • Evaluation of treatment outcomes for both mother and fetus.

Main Results:

  • Pregnancy can affect pituitary adenoma size and GH/IGF-1 secretion.
  • GH/IGF-1 hypersecretion poses risks to maternal and fetal health.
  • Pituitary surgery and medical treatments (dopamine agonists, somatostatin analogs, GH receptor antagonist) have varying safety profiles in pregnancy.

Conclusions:

  • Multidisciplinary management is crucial for pregnant women with acromegaly.
  • Treatment decisions must balance tumor control with maternal-fetal well-being.
  • Further research is needed to optimize therapeutic strategies during pregnancy.