Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Race and Ethnicity With Computed Tomography Head Utilization in Children Presenting to the Emergency Department With an Unprovoked Seizure.

Pediatric neurology·2026
Same author

Implementation of High-Flow Nasal Cannula and Noninvasive Ventilation During Pediatric Interfacility Transport: Effect on Intubation Rates.

Air medical journal·2026
Same author

Quality and readability of chatbot responses to patient questions: A systematic cross-sectional meta-synthesis.

Health informatics journal·2025
Same author

Understanding medical students' knowledge and attitudes about cerebral palsy.

PM & R : the journal of injury, function, and rehabilitation·2025
Same author

New Processes for Ionizing Nonvolatile Compounds in Mass Spectrometry: The Road of Discovery to Current State-of-the-Art.

Journal of the American Society for Mass Spectrometry·2024
Same author

Oral enteral nutrition in the emergency department for children with bronchiolitis hospitalized on high flow nasal cannula.

The American journal of emergency medicine·2024

Related Experiment Video

Updated: May 30, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Remote ischemic preconditioning: current knowledge, unresolved questions, and future priorities.

Karin Przyklenk1, Peter Whittaker

  • 1Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA. kprzykle@med.wayne.edu

Journal of Cardiovascular Pharmacology and Therapeutics
|August 9, 2011
PubMed
Summary
This summary is machine-generated.

Remote ischemic preconditioning (RIPC) protects the heart by applying brief ischemia to distant tissues. While RIPC shows clinical promise, its underlying protective mechanisms remain unclear.

More Related Videos

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
07:46

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Published on: May 9, 2013

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Related Experiment Videos

Last Updated: May 30, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
07:46

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Published on: May 9, 2013

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Area of Science:

  • Cardiology
  • Physiology
  • Molecular Biology

Background:

  • Remote ischemic preconditioning (RIPC) is a protective phenomenon.
  • Brief ischemia-reperfusion in distant tissues confers myocardial resistance to sustained ischemia.
  • RIPC has demonstrated infarct size reduction in various models.

Purpose of the Study:

  • To review the current understanding of RIPC.
  • To explore the diverse applications and temporal modifications of RIPC.
  • To highlight the progress in translating RIPC to clinical settings.

Main Methods:

  • Review of existing literature on RIPC.
  • Analysis of studies documenting infarct size reduction via RIPC.
  • Examination of clinical trials investigating RIPC in patients undergoing procedures.

Main Results:

  • RIPC effectiveness documented through intra-cardiac, inter-cardiac, and interorgan protection.
  • RIPC has been successfully applied in remote nociception models.
  • Clinical studies show RIPC attenuates cardiac enzyme release post-surgery.

Conclusions:

  • RIPC is a promising cardioprotective strategy with expanding applications.
  • Temporal modifications like remote perconditioning and postconditioning enhance RIPC.
  • Understanding RIPC's communication mechanisms is crucial for further development.