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Perioperative management of patients with von Willebrand's disease
1Department of Anaesthesia, University of Manitoba, Children's Hospital, Winnipeg, Canada.
Insights
This review examines Factor VIII in Von Willebrand
Area of Science:
- Hematology
- Molecular Biology
- Pathophysiology
Background:
- Von Willebrand's disease (VWD) is a bleeding disorder.
- Factor VIII (FVIII) plays a crucial role in hemostasis.
- Understanding FVIII pathophysiology is key to managing VWD.
Purpose of the Study:
- To review the pathophysiology of Factor VIII in relation to Von Willebrand's disease.
- To outline the perioperative diagnosis and management strategies for VWD.
- To discuss 1-Deamino-8-D-arginine vasopressin (DDAVP) as a treatment alternative.
Main Methods:
- Literature review focusing on Factor VIII and VWD.
- Analysis of diagnostic and management approaches for VWD.
- Evaluation of DDAVP in bleeding diathesis management.
Main Results:
- Identified three major categories of Von Willebrand's disease.
- Reviewed perioperative diagnosis and management protocols.
- Presented DDAVP as a viable alternative to blood product transfusions.
Conclusions:
- Effective management of Von Willebrand's disease requires understanding FVIII pathophysiology.
- Perioperative strategies are crucial for patient safety.
- DDAVP offers a promising alternative for managing bleeding in VWD patients.
Abstract:
This review focuses on the pathophysiology of the Factor VIII molecule as it relates to Von Willebrand's disease. Three major categories of Von Willebrand's disease are identified. The perioperative diagnosis and management of all categories are reviewed. 1-Deamino-8-D-arginine vasopressin (DDAVP) is presented as an alternative to the transfusion of blood and blood products for the management of a bleeding diathesis.