Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

Inflammation

Inflammation

Inflammation: Introduction

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

Acute Inflammation I: Inflammatory Response

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Why m.L.T.j. ?

Muscles, ligaments and tendons journal·2013

Same author

Plantar pressure of clipless and toe-clipped pedals in cyclists - A pilot study.

Muscles, ligaments and tendons journal·2013

Same author

Persistent HyperCKemia in Athletes.

Muscles, ligaments and tendons journal·2013

Same author

Chronic peripheral administration of serotonin inhibits thyroid function in the rat.

Muscles, ligaments and tendons journal·2013

Same author

Thicker Achilles tendons are a risk factor to develop Achilles tendinopathy in elite professional soccer players.

Muscles, ligaments and tendons journal·2013

Same author

Why I.s.mu.L.T?

Muscles, ligaments and tendons journal·2013

Search research articles

Related Experiment Video

Updated: May 30, 2026

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

Inflammation in overuse tendon injuries.

Lucy Battery¹, Nicola Maffulli

¹Centre for Sports and Exercise Medicine, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Mile End Hospital, London, England.

Sports Medicine and Arthroscopy Review

|August 9, 2011

Summary

Tendinopathy, characterized by tendon pain and dysfunction, may be linked to obesity and diabetes. Chronic inflammation in these conditions might contribute to the development of tendinopathy, impacting treatment strategies.

More Related Videos

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Related Experiment Videos

Last Updated: May 30, 2026

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Area of Science:

Orthopedics
Sports Medicine
Metabolic Diseases

Background:

Overuse tendon injuries, now termed tendinopathy, involve pain and reduced limb function.
Histopathological findings suggest a "failed healing response" rather than simple inflammation or degeneration.
The exact causes of tendinopathy remain unclear.

Purpose of the Study:

To explore the theoretical link between metabolic conditions and tendinopathy development.
To investigate if obesity and diabetes predispose individuals to tendinopathy.
To consider the implications of this relationship for tendinopathy management.

Main Methods:

Review of existing literature on tendinopathy, obesity, diabetes, and inflammation.
Theoretical analysis of the potential pathomechanisms connecting these conditions.
Discussion of the clinical implications for patient management.

Main Results:

Tendinopathy incidence is higher in individuals with obesity and decreased insulin sensitivity (diabetes).
These patient groups often have chronic low-grade systemic inflammation.
A theoretical basis exists for these conditions predisposing to tendinopathy.

Conclusions:

Obesity and diabetes, associated with chronic inflammation, may increase the risk of developing tendinopathy.
Understanding this link could lead to improved prevention and management strategies for tendinopathy.
Further research is warranted to elucidate the precise mechanisms involved.