Related Experiment Video
Updated: May 30, 2026
Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
[Study on intra-gastric floating beads of naringenin]
Hui-ming Jiang1, Liang-ke Zhang, Pei Yuan
1School of Pharmacy, Chongqing 400016, China. j_h_m_t_h@yahoo.com.cn
Objective:
To prepare calcium alginate-chitosan intra-gastric floating beads of naringenin combining with the solid dispersion method and investigate the in vitro floating characteristics, entrapment efficiency and drug release property of the beads.
Methods:
The solid dispersion of naringenin was prepared by the Eudragit RLPO. Sodium alginate solution mixed with the powder of the solid dispersion of naringenin and frother was slowly dripped into chitosan-calcium chloride solution added with acetic acid. Calcium alginatechitosan intra-gastric floating beads of naringenin were obtained after drying. The effects of solid dispersion on in vitro release of naringenin were investigated.
Results:
Intra-gastric floating beads of naringenin were acquired successfully. More than 70% of the beads kept floating in artificial gastric juice in 9 h, the release ratio of naringenin during 9 h was 65%-70% and the entrapment efficiency was about 70%-80%.
Conclusion:
The sustained release of naringenin in the calcium alginate-chitosan intra-gastric floating beads could be achieved by using the solid dispersion method and it provides some ideas of intra-gastric floating preparations.
More Related Videos
14:05Generation of Hook Ischemia-Reperfusion Model using a Three-Day Developing Chick Embryo
Published on: February 19, 2022
14:18Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
Published on: October 13, 2023
