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Intubation-mediated Intratracheal (IMIT) Instillation: A Noninvasive, Lung-specific Delivery System
Published on: November 17, 2014
Inhalative administration of insulin using a new bubble jet atomization device
Junko Hisasue1, Satoru Fukuyama, Noriaki Nakagaki
1Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
Fukuoka Igaku Zasshi = Hukuoka Acta Medica
|August 10, 2011
Summary
A new bubble jet atomization device effectively delivered inhaled insulin to rats, significantly lowering blood glucose levels. This technology demonstrates potential for non-invasive insulin therapy, maintaining insulin
Area of Science:
- Pharmacology
- Biotechnology
- Medical Devices
Background:
- Inhalative insulin administration offers a non-invasive alternative to injections.
- Developing efficient atomization devices is crucial for effective inhaled insulin delivery.
- Maintaining insulin bioactivity during atomization is essential for therapeutic efficacy.
Purpose of the Study:
- To evaluate a novel bubble jet atomization device for inhalative insulin delivery.
- To confirm the hypoglycemic effect of inhaled insulin in normal rats.
- To assess the device's ability to maintain insulin bioactivity.
Main Methods:
- Wistar rats received intratracheal administration of inhaled insulin (15 U/kg) or a control solution via a bubble jet atomization device.
- Blood glucose concentrations were monitored at multiple time points post-administration.
- Statistical analysis compared glucose levels between the insulin and control groups.
Main Results:
- Inhaled insulin significantly reduced blood glucose levels compared to the control group at 20, 60, and 120 minutes.
- The most substantial glucose reduction was observed at 120 minutes post-inhalation.
- The bubble jet device successfully atomized insulin, leading to a measurable hypoglycemic effect.
Conclusions:
- The novel bubble jet atomization device effectively delivers inhaled insulin.
- This technology demonstrates a significant hypoglycemic effect in rats.
- The device preserves insulin bioactivity, indicating its potential for therapeutic applications.
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