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Published on: January 14, 2014
Neurocytomas: long-term experience of a single institution
A Hallock1, B Hamilton, L C Ang
1Department of Oncology, University of Western Ontario, London, Ontario, Canada.
Neuro-Oncology
|August 10, 2011
Summary
This study reviews 19 neurocytoma cases over 25 years, finding surgery offers durable local control with low risk of permanent deficits. Salvage therapies are effective for recurrent tumors, improving survival outcomes.
Area of Science:
- Neurosurgery
- Oncology
- Neuropathology
Background:
- Neurocytomas are rare tumors with limited data on treatment outcomes and toxicities.
- A 25-year retrospective review was conducted at a tertiary center to analyze neurocytoma cases.
Observation:
- Nineteen patients with cerebral neurocytomas (median age 31) treated between 1984-2009 were analyzed.
- Primary treatment was surgery (18/19), with one receiving adjuvant radiotherapy.
- Median follow-up was 104.5 months.
Findings:
- Crude local control rates after initial surgery were 68% overall and 74% for central neurocytomas.
- Ten-year overall and relapse-free survival rates were 82% and 62% for all cases.
- Ten patients experienced grade 3/4 toxicity, with one perioperative death; 9 had late grade 3/4 toxicities.
Implications:
- Initial surgical management provides durable local control for a majority of neurocytoma patients.
- Salvage therapies, including surgery and radiation, are effective for managing tumor recurrence.
- The study highlights a low risk of significant permanent deficits following initial surgery for neurocytomas.
