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Using the continual reassessment method to estimate the minimum effective dose in phase II dose-finding studies: a

Sarah Zohar1, Matthieu Resche-Rigon, Sylvie Chevret

  • 1INSERM U717, Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Paris 7 University, France. sarah.zohar@univ-paris-diderot.fr

Clinical Trials (London, England)
|August 10, 2011
PubMed
Summary

The Continual Reassessment Method effectively estimates the minimum effective dose in phase II clinical trials. This adaptive statistical approach, applied to a real case study, identified the optimal dose for stem cell collection in patients.

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