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Published on: July 5, 2021
Therapy and prognosis of intracranial invasive olfactory neuroblastoma
Guang-Yi Jiang1, Fang-Cheng Li, Wen-Kuan Chen
1Department of Neurosurgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Objective:
There is currently no consensus on a standardized treatment strategy for olfactory neuroblastoma (ONB), especially for intracranial invasion. This purpose of this study is to explore the appropriate treatment modality and prognostic factors of intracranial invasive ONB.
Study Design:
Case series with chart review.
Setting:
The study was conducted at the Sun Yat-sen Memorial Hospital and the Cancer Center of Sun Yat-sen University, China.
Subjects And Methods:
Twenty-five cases of intracranial invasive ONB were collected and investigated using a retrospective review analysis from patients diagnosed between 1980 and 2005.
Results:
The 1-, 3-, and 5-year overall survival rates for the group were 55%, 46%, and 31%, respectively. The subgroups who did not receive surgical treatment had worse survival rates than those who did receive treatment. In particular, patients who did not receive any therapy did not live past 1 year. In contrast, the group of patients treated by intranasal resection in combination with radiotherapy and/or chemotherapy showed a slightly better survival rate. It is important to note that the group of patients treated by craniofacial surgery combined with radiotherapy and/or chemotherapy had a markedly favorable prognosis, with 1-, 3-, and 5-year overall survival rates of up to 100%, 88%, and 66%, respectively.
Conclusions:
Craniofacial surgery in combination with radiotherapy and/or chemotherapy was an effective treatment for intracranial invasive ONB. In addition, it was found that age may not be an important prognostic factor for intracranial invasive ONB; however, the rate of intracalvarial invasion was found to be a potent marker for predicting the prognosis of patients.
Insights
For olfactory neuroblastoma with intracranial invasion, craniofacial surgery combined with radiation and chemotherapy offers the best survival outcomes. Intracalvarial invasion is a key prognostic factor, while age is not significant.
Area of Science:
- Oncology
- Neurosurgery
- Radiotherapy
Background:
- Olfactory neuroblastoma (ONB) lacks a standardized treatment, particularly for intracranial invasion.
- Effective treatment strategies and prognostic indicators for intracranial ONB are needed.
Purpose of the Study:
- To determine the optimal treatment modality for intracranial invasive ONB.
- To identify prognostic factors influencing patient survival.
Main Methods:
- Retrospective case series analysis of 25 patients with intracranial invasive ONB diagnosed between 1980 and 2005.
- Review of treatment strategies including surgery, radiotherapy, and chemotherapy.
- Evaluation of survival rates and prognostic factors such as age and extent of invasion.
Main Results:
- Overall 1-, 3-, and 5-year survival rates were 55%, 46%, and 31%.
- Patients undergoing craniofacial surgery with adjuvant therapy showed significantly better survival (100% 1-year, 88% 3-year, 66% 5-year).
- Intracalvarial invasion was a strong negative prognostic marker, whereas age was not significant.
Conclusions:
- Craniofacial surgery combined with radiotherapy and/or chemotherapy is an effective treatment for intracranial invasive ONB.
- The extent of intracalvarial invasion is a critical prognostic factor.
- Age is not a significant predictor of prognosis in these patients.
