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Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
Data Collection by Observations01:08

Data Collection by Observations

Data collection refers to a systematic way of obtaining, observing, measuring, and analyzing accurate information. Observational studies are one of the most widely used methods of data collection. It involves collecting data by observing the behavior and physical characteristics of a sample without making any modifications to the sample.
An astronomer viewing the motion and brightness of stars in the sky and recording the data is an example of observational data collection. A botanist recording...
Lifestyle Factors and Health01:20

Lifestyle Factors and Health

Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...

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Related Experiment Video

Updated: May 30, 2026

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

The Lifestyle Interventions and Independence for Elders Study: design and methods.

Roger A Fielding1, W Jack Rejeski, Steven Blair

  • 1Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. roger.fielding@tufts.edu

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|August 10, 2011
PubMed
Summary

The Lifestyle Interventions and Independence for Elders (LIFE) Study investigated if physical activity prevents major mobility disability in older adults. Results are expected to inform public health strategies for aging populations.

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Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
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Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
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Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
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Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

Area of Science:

  • Gerontology
  • Public Health
  • Clinical Trials

Background:

  • Maintaining functional independence in older adults is a public health priority.
  • Mobility loss in seniors is linked to adverse health outcomes and reduced quality of life.
  • Evidence is lacking on preventing major mobility disability through physical activity.

Purpose of the Study:

  • To determine if a supervised physical activity program can prevent major mobility disability in sedentary older adults.
  • To compare the efficacy of physical activity versus health education in promoting successful aging.
  • To address the need for Phase 3 evidence on mobility disability prevention.

Main Methods:

  • The Lifestyle Interventions and Independence for Elders (LIFE) Study is a Phase 3 multicenter randomized controlled trial.
  • 1,600 sedentary older adults were randomized to either a physical activity program or a health education program.
  • Participants were followed for an average of 2.7 years.

Main Results:

  • The primary outcome is major mobility disability, defined as the inability to walk 400 meters.
  • Secondary outcomes include cognitive function, fall injuries, and activities of daily living.
  • Cost-effectiveness and combined outcomes (disability or death) were also assessed.

Conclusions:

  • The study's findings will have significant public health implications.
  • Results will inform interventions for the growing population of older adults.
  • Evidence from this trial is crucial for promoting independence in aging.