Brown's syndrome
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Updated: May 30, 2026

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Published on: March 23, 2022
Donelson R Manley1, Rizwan A Alvi
1Pediatric Ophthalmology and Ocular Genetics Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5109, USA. donelson.manley@verizon.net
Purpose Of Review:
To better understand the various causes of Brown's syndrome, provide a historical account of the progression of Brown's syndrome, and to bring attention to clinical characteristics specific to Brown's syndrome.
Recent Findings:
The inability to elevate an eye in adduction is a common problem with a number of possible causes usually pointing to cyclovertical muscle involvement. The specific cause can usually be determined by either the three-step test or forced ductions. Because Brown's syndrome does not involve a paretic cyclovertical muscle but rather a mechanical muscle limitation, forced ductions instead of the three-step test must be used to evaluate a patient of Brown's syndrome and is crucial in the diagnosis.
Summary:
The recognition of true Brown's syndrome can be accomplished by clinical examination and confirming the diagnosis with a positive forced duction test.
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