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Updated: May 30, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Squamous cell carcinoma of the prostate
Reviews in Urology
|August 10, 2011
Summary
Primary squamous cell carcinoma of the prostate is a rare and aggressive cancer. This case highlights palliative radiation therapy for metastatic disease, suggesting multimodal treatments may improve survival for this rare prostate cancer.
Area of Science:
- Oncology
- Radiation Oncology
Background:
- Squamous cell carcinoma of the prostate (P-SCC) is a rare malignancy, accounting for 0.5% to 1% of all prostate cancers.
- P-SCC is characterized by aggressive behavior and a poor prognosis, with a median survival of approximately 14 months postdiagnosis.
Purpose of the Study:
- To present a case of primary squamous cell carcinoma of the prostate with extensive metastatic disease.
- To discuss the management and outcomes of palliative radiation therapy in a patient with advanced P-SCC.
Main Methods:
- The patient received palliative radiation therapy using a four-field technique with 18 MV photons.
- The prescribed dose was 4000 cGy in 16 fractions (250 cGy per fraction) to the 100% isodose line.
Main Results:
- The case involved a complicated presentation of metastatic disease.
- While no definitive curative treatment exists, palliative radiation was administered due to disease extent.
Conclusions:
- There is no established definitive treatment for squamous cell carcinoma of the prostate.
- Multimodal treatment approaches, combining surgery, chemotherapy, and radiation therapy, show promise for improving survival durations in patients with P-SCC.
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