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Related Experiment Video

Updated: May 30, 2026

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

Upper limb function in adults with Duchenne muscular dystrophy.

Bart Bartels¹, Robert F Pangalila, Michael P Bergen

¹Department of Rehabilitation Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

Journal of Rehabilitation Medicine

|August 10, 2011

Summary

Upper limb function in adults with Duchenne muscular dystrophy (DMD) varies widely. Muscle strength and range of motion are key factors influencing distal motor function in DMD patients.

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Area of Science:

Neurology
Rehabilitation Medicine
Genetics

Background:

Duchenne muscular dystrophy (DMD) is a progressive genetic disorder affecting muscle strength.
Adult patients with DMD often experience significant upper limb functional limitations.

Purpose of the Study:

To assess upper limb function in adults with DMD.
To identify factors associated with upper limb motor function in this population.

Main Methods:

Cross-sectional study of 70 adult men with DMD (ages 20-43).
Utilized the Motor Function Measure for general and distal upper limb function.
Assessed muscle strength and range of motion using dynamometry, manual muscle testing, and goniometry.

Main Results:

General motor function was severely impaired across the cohort.
Significant variability observed in distal upper limb function, muscle strength, and range of motion, particularly in early adulthood.
Muscle strength and range of motion accounted for 76% of the variance in distal upper limb motor function.

Conclusions:

Adults with DMD exhibit substantial variability in upper limb function.
Muscle strength and range of motion are strongly correlated with upper limb functional outcomes.
Maintaining muscle strength and range of motion may improve distal motor function in adult DMD patients.