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Updated: May 30, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Toxicities of targeted agents in advanced renal cell carcinoma

Priti Patel1, Sandy Srinivas

  • 1Stanford University, Stanford, CA 94305, USA.

Current Clinical Pharmacology
|August 11, 2011
PubMed

Insights

Targeted therapies like VEGF inhibitors and mTOR inhibitors improve outcomes for metastatic kidney cancer patients but cause distinct side effects. Understanding these toxicities is key for effective patient management and treatment.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Metastatic kidney cancer treatment has advanced with targeted therapies.
  • Vascular endothelial growth factor (VEGF) inhibitors and mTOR inhibitors are key treatment options.

Purpose of the Study:

  • To review the toxicities associated with VEGF inhibitors and mTOR inhibitors in metastatic kidney cancer.
  • To emphasize the importance of recognizing and managing these treatment-related adverse events.

Main Methods:

  • Literature review of targeted therapies for metastatic kidney cancer.
  • Summary of known toxicity profiles for VEGF and mTOR inhibitors.

Main Results:

  • VEGF inhibitors commonly cause hypertension, fatigue, and hand-foot syndrome.
  • mTOR inhibitors are associated with hyperglycemia and hypertriglyceridemia.

Conclusions:

  • Effective management of metastatic kidney cancer requires understanding the specific toxicities of targeted therapies.
  • Recognizing and addressing adverse events is crucial for optimizing patient care and outcomes.

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