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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Related Experiment Video

Updated: May 30, 2026

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults

Published on: February 8, 2019

Balance and gait problems in the elderly.

Anand Viswanathan1, Lewis Sudarsky

  • 1Stroke Service and Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA. aviswanathanl@partners.org

Handbook of Clinical Neurology
|August 11, 2011
PubMed
Summary
This summary is machine-generated.

Gait and balance disorders are common in older adults, increasing fall risks and impacting independence. This review covers their mechanisms, types, and treatments, highlighting links to vascular disease.

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Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
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Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults

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Related Experiment Videos

Last Updated: May 30, 2026

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

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Published on: February 8, 2019

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
08:56

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults

Published on: November 7, 2014

Area of Science:

  • Gerontology
  • Neurology
  • Biomechanics

Background:

  • Gait and balance problems are prevalent in the aging population.
  • These issues significantly affect elderly independence and increase fall-related injuries.
  • Balance and gait disturbances, though distinct, are often interconnected.

Purpose of the Study:

  • To discuss the anatomical and physiological underpinnings of balance and gait.
  • To review common fall patterns and classify gait disorders in the elderly.
  • To explore the connection between balance/gait issues, subcortical vascular disease, and potential interventions.

Main Methods:

  • Literature review of anatomical and physiological mechanisms.
  • Analysis of common fall patterns and classification of gait disorders.
  • Examination of the relationship with subcortical vascular disease and therapeutic strategies.

Main Results:

  • Detailed discussion of the neuroanatomical and physiological systems governing gait and balance.
  • Categorization of various fall types and a classification system for gait disorders.
  • Exploration of the link between subcortical vascular disease and impaired gait/balance.

Conclusions:

  • Understanding the mechanisms of gait and balance disorders is crucial for the elderly.
  • Interventions targeting these disorders can improve independence and reduce fall risks.
  • Subcortical vascular disease is a significant factor to consider in elderly gait and balance impairments.