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Updated: Feb 11, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
Published on: November 20, 2015
Perivascular Space Progression in Patients with Cerebral Amyloid Angiopathy
Qi Li1,2, Maria Clara Zanon Zotin3,4, Andrew D Warren3
1Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China, qili_md@126.com.
Perivascular spaces (PVS) progression occurs in over a quarter of cerebral amyloid angiopathy (CAA) patients over nearly five years. This progression is linked to cerebral microbleed (CMB) progression, suggesting PVS changes may indicate CAA-related vascular damage.
Area of Science:
- Neurology
- Radiology
- Vascular Dementia Research
Background:
- Dilated perivascular spaces (PVS) are linked to small vessel disease in aging individuals.
- Cerebral amyloid angiopathy (CAA) is a common cause of spontaneous lobar intracerebral hemorrhage in the elderly.
Purpose of the Study:
- To investigate the incidence and evolution of MRI-detectable perivascular spaces (PVS) progression in patients with cerebral amyloid angiopathy (CAA).
Main Methods:
- Included 90 symptomatic CAA patients with baseline and follow-up MRI scans >2 years apart.
- Assessed severity of basal ganglia (BG) and centrum semiovale (CSO) PVS.
- Used multivariable logistic regression to identify risk factors for PVS progression.
Main Results:
- PVS progression was observed in 26.7% of patients over a median of 4.8 years.
- Cerebral microbleed (CMB) progression and baseline intracerebral hemorrhage (ICH) predicted overall PVS progression.
- ICH and hypertension predicted BG-PVS progression, while CMB progression predicted CSO-PVS progression.
Conclusions:
- Perivascular spaces (PVS) progression is observed in a significant subset of CAA patients.
- CMB progression is associated with PVS progression in CAA.
- PVS progression may serve as a neuroimaging marker for CAA-related vascular changes.
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