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Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
The Spindle Assembly Checkpoint02:19

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Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control
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Templated assembly by selective removal: simultaneous, selective assembly and model verification.

Feras Eid1, Sunghwan Jung, Carol Livermore

  • 1Massachusetts Institute of Technology, Department of Mechanical Engineering, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Nanotechnology
|August 11, 2011
PubMed
Summary
This summary is machine-generated.

This study demonstrates templated assembly for precisely placing silica microspheres of two sizes onto surfaces. The method achieves high assembly yield, validated by a predictive model, for applications in microfabrication.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Surface Science

Background:

  • Templated assembly is crucial for precise micro/nanoscale fabrication.
  • Selective removal techniques offer potential for controlled particle placement.
  • Simultaneous assembly of multiple particle sizes presents a significant challenge.

Purpose of the Study:

  • To demonstrate simultaneous and selective assembly of silica microspheres with two different diameters onto a surface.
  • To investigate the influence of fluid composition and excitation intensity on assembly yield.
  • To validate a predictive model for templated assembly yield.

Main Methods:

  • Utilized templated assembly by selective removal.
  • Employed silica microspheres of 636 nm and 2 µm diameters.
  • Assembled particles from a fluid onto patterned templates with matching hole geometries.
  • Varied fluid compositions and excitation intensities during experiments.

Main Results:

  • Successfully demonstrated simultaneous assembly of two distinct silica microsphere sizes.
  • Achieved excellent agreement between experimental assembly yields and model predictions.
  • Identified a critical ratio of moments for high assembly yield, contingent on sufficient fluid stirring.

Conclusions:

  • Templated assembly by selective removal is an effective method for precise, multi-size particle placement.
  • The validated model accurately predicts assembly yield across various experimental conditions.
  • Optimizing fluid dynamics and component retention forces is key to maximizing assembly efficiency.