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Updated: May 30, 2026
Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis
Published on: March 7, 2018
Impact of the self-assembly of multilayer polyelectrolyte functionalized gold nanorods and its application to
1Centre for Optical and Electromagnetic Research, Zhejiang University, Zijingang Campus, Hangzhou 310058, People's Republic of China. Joint Research Center of Photonics of the Royal Institute of Technology (Sweden) and Zhejiang University, Zhejiang University, Zijingang Campus, Hangzhou 310058, People's Republic of China.
Abstract:
Multilayered polyelectrolyte functionalized gold nanorods (GNRs) are reported for the conjugation of and sensitive detection of bio-molecules. Multilayered polyelectrolyte functionalized GNRs can significantly improve the biocompatibility of cetyltrimethylammonium bromide (CTAB) coated GNRs in a bio-environment and can diminish the toxicity induced by CTAB. Biotin, bovine serum albumin (BSA)-biotin and streptavidin are conjugated to polyelectrolyte functionalized GNRs, and the conjugates can serve as a platform for many biotin-streptavidin-based biological applications. Through the robust self-assembly effect of GNRs, biotin-conjugated GNRs are also utilized as a very sensitive probe for the detection of a small amount of streptavidin.
