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Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Diverticular Disease of the Colon

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

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Related Experiment Video

Updated: May 30, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

[Colorectal cancer].

Masatoshi Oya¹, Shinichi Sameshima, Nobumi Tagaya

¹First Dept. of Surgery, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|August 11, 2011

Summary

Neoadjuvant therapy offers a new option for marginally resectable colorectal cancer. Ongoing trials will clarify the effectiveness of chemotherapy and chemoradiation for these challenging cases.

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Last Updated: May 30, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

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A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Area of Science:

Oncology
Surgical Oncology
Gastroenterology

Context:

Advances in chemotherapy and chemoradiation have introduced neoadjuvant treatment for select colorectal cancer cases.
Marginally resectable colorectal cancer (mCRC) lacks a precise definition, encompassing lesions requiring extensive surgery or those with poor prognostic factors.

Purpose:

To define criteria for marginally resectable colorectal cancer.
To explore the role of neoadjuvant therapy in improving outcomes for mCRC.

Summary:

Marginally resectable colorectal cancer includes primary lesions needing extended resection, those with unfavorable prognostic factors like extensive lymph node metastasis, locally recurrent tumors, and specific liver metastases.
Neoadjuvant chemotherapy regimens (e.g., oxaliplatin, irinotecan with targeted agents) and chemoradiation are being investigated to improve curability for mCRC.
Ongoing clinical trials aim to establish the efficacy of neoadjuvant treatment for mCRC.

Impact:

Improved understanding of mCRC criteria can guide treatment decisions.
Neoadjuvant strategies may enhance surgical outcomes and patient prognosis for mCRC.
Further research is crucial to optimize neoadjuvant treatment protocols for mCRC.