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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Published on: February 27, 2011

Multiple-mouse neuroanatomical magnetic resonance imaging.

Jun Dazai¹, Shoshana Spring, Lindsay S Cahill

¹Mouse Imaging Centre, Hospital for Sick Children.

Journal of Visualized Experiments : Jove

|August 11, 2011

Summary

Magnetic Resonance Imaging (MRI) offers advanced tools for mouse phenotyping, aiding in the study of human disease models. This technique enables rapid characterization of genetic mutations through detailed anatomical and physiological imaging.

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Published on: February 27, 2011

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Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Published on: July 12, 2012

Area of Science:

Neuroimaging
Biomedical Engineering
Genetics

Background:

Magnetic Resonance Imaging (MRI) is increasingly vital for mouse phenotyping.
It aids in characterizing genetically altered mouse models of human diseases.
High-field scanners and simultaneous multi-mouse imaging accelerate the study of novel mutations.

Purpose of the Study:

To describe general methods for acquiring quality mouse phenotyping images using MRI.
Focus on anatomical phenotyping as a key application.
Highlight practical considerations for both in vivo and ex vivo mouse brain imaging.

Main Methods:

Utilizing a system for concurrent mouse imaging in shielded radio frequency (RF) coils.
Concurrent scanning within a common magnet.
Detailed discussion of practical considerations for in vivo and ex vivo brain imaging.

Main Results:

The described methods facilitate high-quality image acquisition for mouse phenotyping.
Anatomical phenotyping demonstrates significant potential impact in various mouse models.
Concurrent imaging enhances efficiency in phenotyping studies.

Conclusions:

Effective mouse MRI phenotyping requires careful experimental design.
The described MRI techniques provide valuable tools for neuroanatomy and physiology research.
This approach supports the evaluation of mouse models for human disease research.