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Updated: May 30, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Intraoperative spectral-domain optical coherence tomography during complex retinal detachment repair
Lyndon B Lee1, Sunil K Srivastava
1Emory Eye Center (LBL), Emory University, Atlanta, Georgia, USA.
Abstract:
Spectral-domain optical coherence tomography (SD-OCT) is a non-invasive imaging modality that generates detailed images of retinal microstructure. In this study, this technology was employed to investigate changes that occur intraoperatively during repair of complex rhegmatogenous retinal detachment using perfluorocarbon liquids. Intraoperative SD-OCT images were obtained for two patients who underwent pars plana vitrectomy, perfluoro-n-octane instillation, and silicone oil fill for rhegmatogenous retinal detachment. The results demonstrate the ability to obtain high-resolution images of retinal architecture intraoperatively through perfluoro-n-octane and silicone oil. Residual subretinal fluid may be identified intraoperatively despite tamponade with perfluoro-n-octane.

