Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma-IV: Nursing Management

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Antiasthma Drugs: β2-Adrenoceptor Agonists

Antiasthma Drugs: β₂-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantifying Proximal Tibial Physeal Injury in Rigid Intramedullary Nailing in Adolescent Patients.

Journal of pediatric orthopedics·2026

Same author

Crystal-facet-directed all-vacuum-deposited perovskite solar cells.

Nature materials·2026

Same author

Transient Unexplained Severe Acute Hyperbilirubinaemia and Cholestasis in a Patient With Hereditary Spherocytosis.

Case reports in hepatology·2026

Same author

Certolizumab-associated autoimmune-like hepatitis.

BMJ case reports·2025

Same author

Rodent Pathogen Detection via Testing of Soiled Nesting Material.

Journal of the American Association for Laboratory Animal Science : JAALAS·2025

Same author

Lead the room: Impact of leadership style on team resilience among trainees in the trauma bay.

The journal of trauma and acute care surgery·2025

Same journal

The economic burden of MASH: comparison of healthcare resource utilization and costs in patients with probable MASH, without MASH, and with diagnosed MASH.

Expert review of pharmacoeconomics & outcomes research·2026

Same journal

Comparative landscape of artificial intelligence-assisted systematic literature reviews.

Expert review of pharmacoeconomics & outcomes research·2026

Same journal

Single versus multiple inhaler triple therapy in COPD using data from the pragmatic INTREPID trial: cost-effectiveness analysis from the Chilean public healthcare system perspective.

Expert review of pharmacoeconomics & outcomes research·2026

Same journal

Real-world direct medical costs and resource utilization of immune checkpoint inhibitors in advanced NSCLC with COPD: a multicenter cost-consequence analysis from Iraq.

Expert review of pharmacoeconomics & outcomes research·2026

Same journal

TENS in chronic pain management: a 11-year nationwide analysis using the French National Health Data System.

Expert review of pharmacoeconomics & outcomes research·2026

Same journal

Economic burden of breast cancer in Cyprus from a societal perspective.

Expert review of pharmacoeconomics & outcomes research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 30, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Asthma outcome measures.

Joannie Shen¹, Michael Johnston, Ron D Hays

¹Air Pollution and Respiratory Health Branch/National Center for Environmental Health/Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. gmq6@cdc.gov

Expert Review of Pharmacoeconomics & Outcomes Research

|August 12, 2011

Summary

This summary is machine-generated.

This review discusses asthma outcome measures, emphasizing the need to harmonize metrics for clinical trials. It highlights the shift towards patient-reported outcomes for assessing long-term asthma control.

More Related Videos

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Related Experiment Videos

Last Updated: May 30, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

Pulmonology and Respiratory Medicine
Clinical Trial Design
Health Outcomes Research

Background:

Asthma is a chronic airway inflammatory disease with complex, heterogeneous mechanisms.
Traditional asthma management and clinical trials prioritized lung function and exacerbation reduction.
Recent guidelines emphasize patient-reported outcomes (PROs) for assessing asthma control, including quality of life.

Purpose of the Study:

To review common asthma outcome measures used in clinical practice and research.
To highlight recent efforts in harmonizing outcome measures for asthma therapeutic clinical trials.
To underscore the importance of consistent outcome assessment for comparative analysis across studies.

Main Methods:

Literature review of asthma outcome measures.
Analysis of current asthma guidelines and regulatory requirements (e.g., US FDA).
Examination of efforts to harmonize outcome measures in asthma research.

Main Results:

Lung function and exacerbation rates remain key trial endpoints, particularly for bronchodilator therapy.
Patient-reported outcomes, such as health-related quality of life, are increasingly recognized for assessing long-term asthma control.
Harmonization of outcome measures is crucial for robust comparisons across diverse asthma studies.

Conclusions:

A consensus on harmonized outcome measures is needed for asthma clinical trials.
Integrating PROs alongside traditional measures provides a more comprehensive assessment of asthma control.
Standardized outcome measures will enhance the interpretability and comparability of asthma research findings.