[Development of a secondary malignant tumor in patients with Hodgkin's disease]

Six out of 204 patients with Hodgkin's disease developed second malignant tumours 25, 30, 61, 65, 68 and 130 months following their treatment. The length of follow-up ranged between 24-233 months with a mean value of 95.8 months. Half of the tumours appeared within the volume irradiated. Five patients received radio- and polychemotherapy, only but one radiotherapy alone. The location of tumours found was as follows: 1 melanoma of the skin, 1 adenocarcinoma of the nasopharynx, 1 cancer of the rectum, 1 renal cell cancer as well as two cancers of the lung. Four patients are living following treatment of their secondary tumour. Until now no case of acute leukaemia could be observed.