Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EBUS guided trans-esophgeal cryobiopsy-two case reports.

Lung India : official organ of Indian Chest Society·2025
Same author

Endobronchial stenting in a rare case of severe necrotic tracheal mucormycosis.

Lung India : official organ of Indian Chest Society·2024
Same author

Deracemization of Benzoin and its Derivatives via Kinetic, Dynamic Kinetic, Aerobic Oxidative Kinetic, and Reagent-mediated resolution.

Chemistry, an Asian journal·2024
Same author

Corrigendum: "In vivo integration of poly(ε- caprolactone)/gelatin nanofibrous nerve guide seeded with teeth derived stem cells for peripheral nerve regeneration".

Journal of biomedical materials research. Part A·2021
Same author

Non-hematopoietic deficiency of proprotein convertase subtilisin/kexin type 9 deficiency leads to more severe anemia in a murine model of sickle cell disease.

Scientific reports·2020
Same author

Biocompatibility evaluation of electrically conductive nanofibrous scaffolds for cardiac tissue engineering.

Journal of materials chemistry. B·2020

Related Experiment Video

Updated: May 30, 2026

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds
09:29

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

Published on: August 16, 2014

Surface modified electrospun nanofibrous scaffolds for nerve tissue engineering.

Molamma P Prabhakaran, J Venugopal, Casey K Chan

    Nanotechnology
    |August 12, 2011
    PubMed
    Summary

    Plasma-treated poly-ε-caprolactone (PCL) nanofibrous scaffolds enhance Schwann cell adhesion and proliferation, offering a cost-effective alternative for nerve tissue engineering compared to collagen-based scaffolds.

    More Related Videos

    Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
    09:32

    Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

    Published on: April 19, 2015

    Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells
    08:03

    Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells

    Published on: June 18, 2014

    Related Experiment Videos

    Last Updated: May 30, 2026

    Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds
    09:29

    Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

    Published on: August 16, 2014

    Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
    09:32

    Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

    Published on: April 19, 2015

    Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells
    08:03

    Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells

    Published on: June 18, 2014

    Area of Science:

    • Biomaterials Science
    • Tissue Engineering
    • Regenerative Medicine

    Background:

    • Biodegradable polymeric scaffolds with tailored surface properties are crucial for biomedical applications.
    • Poly-ε-caprolactone (PCL) nanofibrous scaffolds are promising for nerve tissue formation.
    • Surface modification is key to enhancing cell-material interactions.

    Purpose of the Study:

    • To develop and evaluate surface-modified PCL nanofibrous scaffolds for enhanced Schwann cell interactions.
    • To compare the efficacy of plasma-treated PCL scaffolds with PCL/collagen scaffolds for nerve regeneration.
    • To assess the cost-effectiveness and potential of modified PCL scaffolds in peripheral nerve repair.

    Main Methods:

    • Fabrication of PCL nanofibrous scaffolds using electrospinning.
    • Surface modification of PCL scaffolds via a simple plasma treatment process.
    • Evaluation of scaffold hydrophilicity using contact angle and X-ray photoelectron spectroscopy.
    • Assessment of Schwann cell adhesion, proliferation, and morphology on scaffolds.

    Main Results:

    • Plasma treatment significantly enhanced the hydrophilicity of PCL nanofibrous scaffolds.
    • Surface-modified PCL (p-PCL) scaffolds demonstrated a 17% increase in Schwann cell proliferation compared to PCL/collagen scaffolds after 8 days.
    • Schwann cells exhibited normal morphology and bipolar elongations on p-PCL scaffolds.
    • p-PCL scaffolds proved to be a more cost-effective material than PCL/collagen scaffolds.

    Conclusions:

    • Plasma-treated PCL nanofibrous scaffolds provide a cost-effective and promising alternative to natural polymer composites for peripheral nerve regeneration.
    • The enhanced Schwann cell adhesion and proliferation on p-PCL scaffolds support their potential as ideal tissue-engineered constructs for nerve repair.
    • Surface modification via plasma treatment is an effective strategy to improve the biocompatibility of PCL scaffolds for neural applications.