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Related Concept Videos

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Related Experiment Video

Updated: May 1, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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EBUS guided trans-esophgeal cryobiopsy-two case reports.

S Santhakumar1, Karan Deshmukh1, Sangita Sharma Mehta2

  • 1Department of Pulmonology, KMCH, Coimbatore, Tamil Nadu, India.

Lung India : Official Organ of Indian Chest Society
|April 29, 2025
PubMed
Summary
This summary is machine-generated.

Endobronchial ultrasound (EBUS) guided mediastinal cryobiopsy offers larger tissue samples for better diagnosis. This novel technique, when performed via the trans-esophageal route (EUS-B-guided cryobiopsy), provides a safe alternative for patients intolerant to bronchoscopic procedures.

Keywords:
Cryobiopsyendobronchial ultrasoundmediastinal adenopathy

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Area of Science:

  • Pulmonology
  • Interventional Bronchoscopy
  • Diagnostic Procedures

Background:

  • Endobronchial ultrasound (EBUS) guided mediastinal cryobiopsy is a novel technique to improve diagnostic yield.
  • While generally safe and superior to EBUS-TBNA alone for tissue acquisition, its safety in patients intolerant to bronchoscopy due to respiratory distress is unclear.
  • Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a well-tolerated alternative with comparable diagnostic yield to EBUS-TBNA.

Purpose of the Study:

  • To evaluate the feasibility and safety of EBUS-guided cryobiopsy via the trans-esophageal route (EUS-B-guided cryobiopsy).
  • To present a novel approach for patients who cannot tolerate standard bronchoscopic procedures.
  • To address inconclusive ROSE reports in challenging cases.

Main Methods:

  • The study reports on two patients who underwent EUS-B-guided cryobiopsy.
  • This trans-esophageal approach was chosen due to patient intolerance to standard bronchoscopic procedures.
  • Rapid on-site evaluation (ROSE) reports were inconclusive in these cases.

Main Results:

  • Successful EUS-B-guided cryobiopsy was performed in both reported patients.
  • The trans-esophageal route proved to be a viable alternative for mediastinal cryobiopsy.
  • This method facilitated adequate tissue acquisition in patients with procedural limitations.

Conclusions:

  • EUS-B-guided cryobiopsy is a safe and effective alternative for mediastinal lesion diagnosis in patients unable to tolerate bronchoscopic procedures.
  • This technique expands the utility of cryobiopsy for challenging patient populations.
  • It offers a valuable option when standard methods are contraindicated or yield inconclusive results.