Herpesviruses: a study of parts

Dormancy, an adaptation to survival in a hostile environment, is a trait common to herpesviruses. Two other features are a large (0.1-0.25 Mb) and mutile (inherently easily mutable) genome. The complete nucleotide sequences of four herpesviruses have recently been determined. This database is unparalleled in allowing the comparative evolutionary study of a complex group of viruses in eukaryotes. In this article, we examine aspects of herpesvirus diversity in the light of recent studies which have revealed characteristics that unify the family at the genetic level.