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Growth hormone gene regulation: a paradigm for cell-type-specific gene activation
M Karin1, J L Castrillo, L E Theill
1Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla 92093.
Trends in Genetics : TIG
|March 1, 1990
Abstract:
The growth hormone (GH) gene is specifically expressed within specialized cells of the anterior pituitary. The central role in GH gene activation is played by GHF-1, a homeodomain protein that is itself specifically expressed in the anterior pituitary.