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Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
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Recent advances and patents in solid dispersion technology.

Babbar Iqbal1, Asgar Ali, Javed Ali

  • 1Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India. babariqbal4u@yahoo.co.in

Recent Patents on Drug Delivery & Formulation
|August 13, 2011
PubMed
Summary

Solid dispersions enhance the solubility and oral bioavailability of poorly water-soluble drugs, particularly BCS class II drugs. This review explores their formulation, applications, limitations, and innovative alternatives for drug delivery.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Materials Science

Background:

  • Poor drug solubility due to high lipophilicity and lattice energy presents significant challenges in pharmaceutical development.
  • Developing effective dosage forms for poorly water-soluble drugs is crucial for oral bioavailability.

Purpose of the Study:

  • To review solid dispersions as a formulation strategy for improving solubility and bioavailability of BCS class II drugs.
  • To discuss the fundamentals, formulation techniques, carriers, applications, and limitations of solid dispersions.
  • To explore alternative approaches, phase transitions, glass transition temperature (Tg), controlled release, in vitro-in vivo correlation (IVIVC), and patent landscape of solid dispersions.

Main Methods:

  • Review of scientific literature and patents on solid dispersion technology.
  • Analysis of formulation strategies, including various carriers and techniques.
  • Discussion of key aspects such as phase transitions, Tg, controlled release, and IVIVC.

Main Results:

  • Solid dispersions offer a viable approach to overcome poor solubility and enhance oral bioavailability.
  • Various formulation techniques and carriers can be employed to create effective solid dispersions.
  • Alternative strategies and innovative solid dispersions show promise for future drug delivery.

Conclusions:

  • Solid dispersions are a critical formulation strategy for improving the delivery of poorly soluble drugs.
  • Understanding the fundamentals and limitations is key to successful application.
  • Ongoing research and patent activity highlight the dynamic and evolving nature of solid dispersion technology.