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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

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Related Experiment Video

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Intelligent hydrogels for drug delivery system.

Liumin He1, Qinhua Zuo, Shasha Xie

  • 1Institutes of life and health engineering, College of life science and technology, Jinan University, Guangzhou 510632, China.

Recent Patents on Drug Delivery & Formulation
|August 13, 2011
PubMed
Summary

Intelligent hydrogels respond to stimuli like temperature and pH, offering advanced capabilities for drug delivery systems. This review explores their applications and recent patent landscape.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Drug Delivery

Background:

  • Intelligent hydrogels, or smart hydrogels, are advanced materials with significant potential in pharmaceutical applications.
  • These hydrogels possess the unique ability to undergo structural changes in response to external stimuli.
  • Their responsiveness makes them highly suitable for controlled and targeted therapeutic interventions.

Purpose of the Study:

  • To review the different types of intelligent hydrogels based on their sensitivity to various stimuli.
  • To explore the diverse applications of intelligent hydrogels in modern drug delivery systems.
  • To summarize recent patent activities related to hydrogel-based drug delivery technologies.

Main Methods:

  • Literature review of intelligent hydrogel properties and applications.
  • Categorization of hydrogels based on stimulus-responsive mechanisms (temperature, pH, electric signal, biochemical molecule, light, pressure).
  • Analysis of recent patents in the field of hydrogel drug delivery.

Main Results:

  • Intelligent hydrogels exhibit sensitivity to a range of external triggers, enabling tunable drug release profiles.
  • Key stimuli include temperature, pH, electric signals, biochemical molecules, light, and pressure.
  • The review highlights numerous applications in targeted drug delivery, controlled release, and theranostics.
  • Recent patents demonstrate ongoing innovation and commercial interest in hydrogel-based drug delivery solutions.

Conclusions:

  • Intelligent hydrogels represent a promising platform for next-generation drug delivery systems.
  • Their stimulus-responsive nature allows for precise control over drug release kinetics and targeting.
  • The patent landscape indicates a dynamic and evolving field with significant future potential.